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Cayman Chemical PAMAM Dendrimer G5 0 Amine w
Supplier: Cayman Chemical 39075500 MG
An amine-terminated PAMAM dendrimer; reduces viability, induces cell cycle arrest at the sub-G1/M phase, and increases LDH release from RAW 264.7 macrophages at 10 UG/ml; induces DNA fragmentation in RAW 264.7 cells at 15 UG/ml; PAMAM G5.0 in complex with siRNA targeting Pou5f1 mRNA, the gene encoding Oct4, reduces Oct4 expression in mouse embryonic stem cells; intravenous administration of PAMAM G5.0 in complex with reporter gene DNA increases reporter gene expression in the lung, spleen, and liver in mice; PAMAM G5.0-gadolinium conjugates increase small vessel contrast quality compared to DTPA-gadolinium conjugates
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