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Cayman Chemical PAMAM DendrImR G4 5 Carboxyl
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Supplier:  Cayman Chemical 39109500 MG

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A STAT3 inhibitor (Ki 10.46 UM) selective for STAT3 over STAT1 (Ki 100 UM) prevents constitutively active STAT3 DNA binding in NIH3T3 fibroblast nuclear extracts (IC50 3.9 UM) cytotoxic to AR230 and imatinib-resistant AR230 cells (IC50s 8.1 and 7 UM respectively) and a variety of glioblastoma CSCs (IC50s 0.195-1.12 UM) reduces tumor growth in MDA-MB-231 breast cancer and U-251MG glioblastoma mouse xenograft models at 3 and 5 mg/kg respectively active against T. gondii at 5 UM

Catalog No. 50-291-7058


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