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Cayman Chemical PamIdronatesodIum salt 50mg
Supplier: Cayman Chemical 2369950 MG
An FPP synthase inhibitor (IC50s = 0.85 and 0.20 µM in J774 cells and for human recombinant FPP synthase, respectively); inhibits bone resorption in rats when used at doses of 16 µmol/kg per day and impairs long bone growth at ≥40 µmol/kg per day; has anti-hypercalcemic effects in a rat hypercalcemia model; high concentrations induce activation of MMP-2, NF-κB, and caspase-3, leading to cell death
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