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Medchemexpress LLC Pamoic acid | 130-85-8 | 99.7% | 388.38 | 10 G
Supplier: Medchemexpress LLC HYW00861310G
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. It exhibits neuroprotective and anti-inflammatory properties.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Exhibits neuroprotective and anti-inflammatory properties.
- Activates GPR35, which may increase the phosphorylation of ERK1/2, initiating an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes.
- Has neuroprotective activity in a mouse model of stroke, reducing infarct size in a GPR35 dependent manner.
- Pamoic acid treatment results in a preferential increment of noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain along with reduced neutrophil counts.
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