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Cayman Chemical PAMP-12humnmouseratp 10mg
Supplier: Cayman Chemical 3691010 MG
An endogenous fragment and MRGPRX2 agonist; inhibits forskolin-induced cAMP accumulation in CHO cells expressing human MRGPRX2 (EC50 = 57.2 nM); selectively induces calcium mobilization in CHO cells expressing MRGPRX2 (EC50 = 41 nM) over those expressing MRGPRX1, MRGPRX3, or MRGPRX4 at 1 µM; an antagonist of nAChRs that inhibits carbachol-induced catecholamine release (IC50 = 1.3 µM) and calcium and sodium influx (IC50s = 0.39 and 0.87 µM, respectively), but not histamine-induced catecholamine release or calcium and sodium influx (IC50s = >1 µM for all), in primary bovine adrenal chromaffin cells; reduces mean arterial blood pressure in normotensive rats at 10 to 50 nmol/kg
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