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Medchemexpress LLC Pan-KRAS-IN-18 | 2937327-83-6 | 99.9% | 450.56 | 5 MG
Supplier: Medchemexpress LLC HY1629605MG
pan-KRAS-IN-18 is a panKRAS inhibitor that inhibits KRAS WT and KRAS G12V with IC50s of 29 and 9 nM, respectively. It exhibits antiproliferative activity in KRAS-mutant cell lines and can be used for lung cancer research.
- Inhibits K-Ras WT (29 nM IC50) and KRas G12V (9 nM IC50)
- Exhibits antiproliferative effects against Ba/F3 KRASG12V and NCI-H727 cells with EC50s of 0.959 and >1 μM, respectively (72 h)
- Shows high clearance in mouse and human liver microsomes
- Displays high binding affinity towards KRASG12V with a Ki of 25 nM
- Appearance is solid, white to off-white
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