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CPC Scientific H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH (trifluoroacetate salt) 1MG
Supplier: CPC Scientific SIGN011A
This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1α (IL-1α) in response to P2X7R activation. ONE-LETTER SEQUENCE: WRQAAFVDSYMOLECULAR FORMULA: C58H79N15O16MOLECULAR WEIGHT:1242.4STORAGE CONDITIONS: -20 5CRESEARCH AREA: Protein Kinases and PhosphatasesREFERENCES: Pelegrin, P. et al. EMBO. J. 25, 5071 (2006); Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007).
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