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Apexbio Technology LLC Pantoprazole 102625-70-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B47205.1
Pantoprazole is an inhibitor of H /K -ATPase frequently utilized in biomedical research to explore mechanisms related to gastric acid secretion and intracellular acidification Upon acid-activated conversion to its sulfenamide derivative pantoprazole irreversibly binds to cysteine residues (Cys813 and Cys822) in gastric parietal cell proton pumps thus suppressing proton transport and subsequent acid secretion Pantoprazole also impairs lysosomal acidification with an IC50 value of approximately 194 M Its reported antimicrobial activity against Helicobacter pylori expands its experimental application making pantoprazole suitable in studies involving gastric physiology proton pump enzymology lysosomal function and bacterial pathogenesis
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