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CPC Scientific H-Thr-Phe-Arg-Gly-Ala-Pro-NH2 (trifluoroacetate salt) 25MG
Supplier: CPC Scientific PARP008B
This peptide is a human PAR-3-derived tethered ligand, which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells. PAR3 Tethered Ligand (Human) / Activates PAR1 and PAR2 This peptide is the 1-6 fragment of the protease-activated receptor 3 (PAR-3), which induces ERK activation in human carcinoma cells endogeneously expressing PAR1 and PAR3. This effect is completely abolished by single alanine substitution at positions 3, 4 and 6 in the peptide. PAR-3 allosterically regulates PAR1 signaling by receptor dimerization governing increased endothelial permeability. Targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation. However this peptide does not affect VEGF release or expression.SEQUENCE: H-Thr-Phe-Arg-Gly-Ala-Pro-NH2 (trifluoroacetate salt)ONE-LETTER SEQUENCE: TFRGAP-NH2MOLECULAR FORMULA: C29H46N10O7MOLECULAR WEIGHT: 646.75STORAGE CONDITIONS: -20 5 CC
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