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AdipoGen PARG Inhibitor PDD00017273 (5 mg)
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Supplier:  AdipoGen AGCR13646M005

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PARG Inhibitor PDD00017273 (5 mg), AdipoGen Life Sciences. Chemical. CAS: 1945950-21-9. Formula: C23H26N6O4S2. MW: 514.6. Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies. Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>30µM). Showed no cytotoxicity (IC50>30µM). Poly(ADP ribose) glycohydrolase (PARG) is a critical component in the repair of single strand DNA breaks and therefore a target in cancer cells. PARG counteracts the function of the ARTD family of poly(ADP ribose) polymerases (known as PARPs) by efficiently catalysing the hydrolysis of O-glycosidic linkages of ADP-ribose polymer, thereby reversing the effects of PARPs.

Catalog No. 50-149-0113


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