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Medchemexpress LLC Paris saponin VII | 68124-04-9 | 5 MG
Supplier: Medchemexpress LLC HYN35845MG
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin from *Trillium tschonoskii*. It induces apoptosis and robust autophagy in K562/ADR cells, demonstrating potential for leukemia treatment. Its action involves Akt/MAPK and P-gp inhibition, attenuating mitochondrial membrane potential, increasing pro-apoptotic proteins like Bax and cytochrome c, and decreasing anti-apoptotic proteins such as Bcl-2, caspases, PARP-1, and p-Akt.
- Isolated from *Trillium tschonoskii*.
- Induces apoptosis and autophagy in K562/ADR cells.
- Inhibits Akt/MAPK and P-gp.
- Attenuates mitochondrial membrane potential.
- Modulates apoptosis-related proteins (e.g., Bax, Bcl-2, caspases).
- Potential for leukemia treatment.
- Inhibits adriamycin-resistant leukemia cell growth.
- Suppresses cell proliferation via G0/G1 arrest.
- Enhances adriamycin's anticancer efficacy in xenograft models.
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