Paromomycin sulfate

Description

Inhibits initiation and elongation during protein synthesis | CAS: 1263-89-4 | C23H47N5O18S | 713.706 g/mol

Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Solubility
Soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Specifications

Chemical Identifiers

• CAS: 1263-89-4
• Molecular Formula: C23H47N5O18S
• Molecular Weight (g/mol): 713.706
• MDL Number: MFCD00079278
• InChI Key: LJRDOKAZOAKLDU-JXDXLELXSA-N
• PubChem CID: 91972180
• IUPAC Name: (3S,5S,6S)-5-amino-2-(aminomethyl)-6-[(2R,4S,5S)-5-[(2R,5R,6R)-3,5-diamino-2-[(2S,3S,5S)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
• SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

• Type: Paromomycin Sulfate
• Physical Form: Powder
• Color: White
• Quantity: 1 g
• Optical Rotation: +51° (c=5 in Water)
• Beilstein: 5715182
• Merck Index: 14,7041
• Solubility Information: Soluble in water
• Formula Weight: 713.71
• Chemical Name or Material: Paromomycin sulfate

Safety and Handling

Hazard Category	H315-H320-H335-H360
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P201-P202-P260-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c
EINECSNumber	215-031-7
RTECSNumber	WK2320000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only