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Medchemexpress LLC Paroxetine (hydrochloride) | 78246-49-8 | 100.0% | 1 ML
Supplier: Medchemexpress LLC HYB049210MM/1ML
Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor and a GRK2 inhibitor with an IC50 of 14 μM. It is used in research for depressive disorders and other biological activities.
- Potent selective serotonin-reuptake inhibitor
- GRK2 inhibitor with an IC50 of 14 μM
- Used for research of depressive disorder
- Restrains T cell migration induced by CX3CL1
- Inhibits GRK2 induced activation of ERK
- Reduces pro-inflammatory cytokines in LPS-stimulated BV2 cells
- Inhibits LPS-induced nitric oxide production and iNOS expression in BV2 cells
- Blocks LPS-induced JNK activation
- Attenuates symptoms of CIA rats and prevents histological damage of joints
- Reduces myocyte cross-sectional area in rats and ROS formation
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