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Medchemexpress LLC Paroxetine hydrochloride hemihydrate | 110429-35-1 | >99.96% | 500 MG
Supplier: Medchemexpress LLC HYB0492A500MG
Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, widely used as an antidepressant. This compound also demonstrates GRK2 inhibitory capabilities with an IC50 of 14 μM. It plays a significant role in restraining T cell migration and inhibiting GRK2-induced ERK activation, which contributes to its anti-inflammatory effects by reducing pro-inflammatory cytokines like TNF-α and IL-1β in LPS-stimulated BV2 cells.
- Restrains T cell migration.
- Inhibits GRK2 induced ERK activation.
- Reduces pro-inflammatory cytokines (TNF-α and IL-1β).
- Relieves microglia-mediated neurotoxicity.
- Attenuates symptoms of CIA rats and decreases LV remodeling.
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