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AdipoGen PARP-1 ARTD1 h pAb
Supplier: AdipoGen AG25T0002R100
Polyclonal Antibody. Recognizes human PARP-1. Cross-reacts weakly with mouse and monkey PARP-1. Source Rabbit. Applications ICC, IHC, IP, WB. Liquid. Contains 0.1% sodium azide. PARP-1 ARTD1 is involved in the base excision repair BER pathway, by catalyzing the polyADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 Th1 cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
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