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AdipoGen PARP10 ARTD10 h mAb 5H11
SDP

Supplier:  AdipoGen AG20T0004L001

Encompass_Preferred

Monoclonal Antibody. Recognizes human PARP-10 ARTD10 with an epitope between aa 256-407, containing the glycine rich G-rich region. Isotype Rat IgG1. Clone 5H11. Applications ICC, IP, WB. Liquid. Cell culture supernatant containing RPMI, 10% FCS and 0.05% sodium azide. PARP-10 is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumor necrosis factor-alpha. PARP-10 monoADP-ribosylates MARylates NEMO NF-kappaB essential modulator, which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival.

Catalog No. 50-256-3360


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