Cayman Chemical ParsaclIsIb 10mg

Supplier:  Cayman Chemical 2978410 MG

A PI3Kδ inhibitor (IC50 = 1 nM); selective for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ (IC50s = >10,000 nM for all), as well as a panel of 192 additional kinases and a panel of 70 ion channels and transporters at 1 µM; inhibits primary human B cell proliferation (IC50 = 0.2 nM) and memory T cell cytokine production (IC50s = 0.2-1.5 nM); inhibits the differentiation of naïve isolated human T cells into Th1, Th2, or Th17 T helper cells; inhibits the proliferation of JeKo-1, Mino, Rec-1, and JVM-2 lymphoma cells (IC50s = 50s = 2-8 nM); reduces intratumoral phosphorylation of Akt and tumor growth in a Pfeiffer mouse xenograft model from 0.1-10 mg/kg; reduces proteinuria, lymphadenopathy, and the severity of skin lesions in an MRL/MpJ-Fas lpr mouse model of spontaneous SLE at 3 mg/kg; reduces salivary levels of TNFSF13B and plasma levels of anti-SSA and anti-SSB autoantibodies in a NOD.ShiLtJ mouse model of Sjögren’s syndrome

Catalog No. 50-298-8909