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Medchemexpress LLC Parsaclisib hydrochloride | 1995889-48-9 | 99.3% | 469.34 | 100 MG
SDP

Catalog No. 5000345072
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Parsaclisib hydrochloride is a potent, selective, and orally active inhibitor of PI3Kδ, exhibiting an IC50 of 1 nM at 1 mM ATP. It demonstrates approximately 20000-fold selectivity over other PI3K class I isoforms and is used for research into relapsed or refractory B-cell malignancies.

  • Potent and selective PI3Kδ inhibitor.
  • Orally active.
  • High selectivity (approximately 20000-fold) over other PI3K class I isoforms.
  • Useful for research of relapsed or refractory B-cell malignancies.
  • Inhibits proliferation of MCL and DLBCL cell lines.
  • Inhibits anti-IgM-induced pAKT (Ser473) in Ramos Burkitt's lymphoma cell line.
  • Inhibits proliferation of human, dog, rat, and mouse primary B cells after receptor activation.
  • Inhibits tumor growth in BALB/c mice bearing A20 murine lymphoma cells.
  • Slows Pfeiffer xenograft tumor growth in a dose-dependent manner and is well tolerated.

Catalog No. 50-003-45072 Supplier Medchemexpress LLC Supplier No. HY109068A50MG
May include imposed supplier surcharges.
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Parsaclisib hydrochloride is a potent, selective, and orally active inhibitor of PI3Kδ, exhibiting an IC50 of 1 nM at 1 mM ATP. It demonstrates approximately 20000-fold selectivity over other PI3K class I isoforms and is used for research into relapsed or refractory B-cell malignancies.

  • Potent and selective PI3Kδ inhibitor.
  • Orally active.
  • High selectivity (approximately 20000-fold) over other PI3K class I isoforms.
  • Useful for research of relapsed or refractory B-cell malignancies.
  • Inhibits proliferation of MCL and DLBCL cell lines.
  • Inhibits anti-IgM-induced pAKT (Ser473) in Ramos Burkitt's lymphoma cell line.
  • Inhibits proliferation of human, dog, rat, and mouse primary B cells after receptor activation.
  • Inhibits tumor growth in BALB/c mice bearing A20 murine lymphoma cells.
  • Slows Pfeiffer xenograft tumor growth in a dose-dependent manner and is well tolerated.

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