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Medchemexpress LLC Parsaclisib hydrochloride | 1995889-48-9 | 99.3% | 469.34 | 25 MG
Supplier: Medchemexpress LLC 25MGHY109068A
Parsaclisib hydrochloride is a potent, selective, and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. It exhibits approximately 20000-fold selectivity over other PI3K class I isoforms. It is used for the research of relapsed or refractory B-cell malignancies.
- Potent, selective, and orally active PI3Kδ inhibitor
- Exhibits approximately 20000-fold selectivity over other PI3K class I isoforms
- Inhibits proliferation of MCL and DLBCL cell lines
- Inhibits anti-IgM-induced pAKT (Ser473) in Ramos Burkitt's lymphoma cell line
- Inhibits proliferation of human, dog, rat, and mouse primary B cells
- Inhibits tumor growth in BALB/c mice bearing A20 murine lymphoma cells
- Slows Pfeiffer xenograft tumor growth in a dose-dependent manner
- Reduces percentage of Tregs (CD4+CD25+FOXP3+) in tumors and spleens
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