AdipoGen Parthenolide

Supplier:  AdipoGen AGCN20455M250

Chemical. CAS 20554-84-1. Formula C15H20O3. MW 248.3. Isolated from Magnolia grandiflora. Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines. At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling pathway. At high concentration induces O2- and causes oxidative-stress-mediated apoptosis. Potent anti-inflammatory and anti-atherosclerotic agent. NF-kappaB inhibitor by directly targeting IkappaB kinase. Inhibits STAT-mediated anti-apoptotic gene transcription. NLRP3 inflammasome inhibitor. Inhibits ATPase activity of NLRP3 and protease activity of caspase 1. Directly binds the pattern recognition receptor NOD2. Specifically inhibits HDAC1 without affecting other class I/II HDACs. DNA methyltransferase 1 DNMT1 inhibitor. Induces ubiquitination of MDM2 resulting in the activation of p53 and other MDM2-regulated tumor suppressor proteins. VEGF inhibitor.

Catalog No. 50-256-2520