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Medchemexpress LLC Pasireotide acetate | 396091-76-2 | 99.5% | 1107.26 | 1 MG
Supplier: Medchemexpress LLC HY16381A1MG
Pasireotide acetate is a long-acting cyclohexapeptide somatostatin analogue. It enhances agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5). This compound can suppress Growth Hormone (GH), Insulin-like Growth Factor-I (IGF-I), and Adrenocorticotropic Hormone (ACTH) secretion, indicating potential effectiveness in treating acromegaly and Cushing's disease.
- Enhances agonist activity at somatostatin receptors
- Suppresses GH, IGF-I, and ACTH secretion
- Exhibits antisecretory, antiproliferative, and proapoptotic activities
- Effectively inhibits GHRH-induced GH release in primary rat pituitary cells
- Decreases serum insulin and increases serum glucose in vivo
- Reduces tumor size and increases apoptosis in Pdx1-Cre mice
- Exerts antinociceptive and antiinflammatory actions via SSTR2 receptor
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