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Cayman Chemical PasIreotIdeaspartatetrIf 10mg
Supplier: Cayman Chemical 2409210 MG
An SSTR agonist; binds selectively to human SST1, SST2, SST3, and SST5 over SST4 (IC50s = 9.3, 1, 1.5, 0.16, and >100 nM, respectively, for human recombinant receptors); dose-dependently inhibits GHRH-stimulated growth hormone release by primary rat anterior pituitary cells; inhibits ACTH secretion by some primary human corticotrope adenomas (10 nM); inhibits ACTH release and proliferation by mouse AtT20 pituitary corticotrope cells in vitro (10 nM); inhibits tumor growth of subcutaneously implanted AtT20 cells in vivo in nude mice (1.5 μg per day); decreases plasma ACTH concentrations and tumor size in dogs with ACTH-dependent Cushing’s disease (0.03 mg/kg)
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