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Apexbio Technology LLC Pazopanib (GW-786034) 444731-52-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A30225.1
Pazopanib (GW-786034 CAS 444731-52-6) is a second-generation multitargeted receptor tyrosine kinase inhibitor selectively targeting vascular endothelial growth factor receptors (VEGFR) platelet-derived growth factor receptors (PDGFR) and c-kit Through blockade of these kinase activities pazopanib suppresses signaling cascades essential for angiogenesis and cellular proliferation Preclinical tumor models indicate that pazopanib alone or combined with chemotherapy demonstrates substantial anti-angiogenic and antitumor efficacy Its distinct inhibitory profile of intracellular VEGFR tyrosine kinases offers valuable applications in oncology research particularly in investigating angiogenesis-driven signaling pathways
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