Apexbio Technology LLC Pazopanib Hydrochloride 635702-64-6 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A83475.1

Pazopanib Hydrochloride (CAS 635702-64-6) is a small-molecule receptor tyrosine kinase inhibitor that targets multiple kinases involved in tumor growth and angiogenesis including VEGFR1 (IC50 10 nM) VEGFR2 (30 nM) VEGFR3 (47 nM) PDGFR (84 nM) FGFR (74 nM) c-Kit (140 nM) and C-FMS (146 nM) By inhibiting these receptors pazopanib suppresses both tumor proliferation and neovascularization Preclinical studies have demonstrated its antitumor activity in various human xenograft models such as renal prostate colon lung melanoma head and neck and breast cancers Pazopanib is employed in research focusing on tumor biology angiogenesis and targeted therapy development

Catalog No. 50-000-96170