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Medchemexpress LLC PB28 dihydrochloride | 172907-03-8 | CB4497464 | 99.6% | 443.49 | 25 MG
Supplier: Medchemexpress LLC 25MGHY108511
PB28 dihydrochloride is a cyclohexylpiperazine derivative, functioning as a high-affinity sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM and a σ1 antagonist with a Ki of 0.38 nM. It demonstrates lower affinity for other receptors. This compound inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. It can modulate SARS-CoV-2-human protein-protein interaction, induces caspase-independent apoptosis, and exhibits antitumor activity.
- Accumulates in the G0-G1 phase for MCF7 and MCF7 ADR cells.
- Inhibits cell growth in MCF7 and MCF7 ADR cells.
- Induces apoptosis via a caspase-independent pathway.
- Reduces P-gp expression in MCF7 and MCF7 ADR cells.
- Displays antiproliferative and cytotoxic effects in C6 rat glioma and SK-N-SH human neuroblastoma cell lines.
- Inhibits tumor growth in Panc02 tumor burden mice.
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