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AdipoGen PBFI
Supplier: AdipoGen CDXP0662M001
Chemical. CAS 124549-11-7. Formula C46H46N2O16. Molecular Weight 882.86. PBFI is a cell-impermeant fluorescent indicator for potassium ions, suitable for detection of physiological concentrations of K in the presence of other monovalent cations. PBFI is used to measure intracellular potassium K fluxes in animal cells and in plant cells and vacuoles. The observation that intracellular K levels are a controlling factor in apoptotic cell death pathways, increased the interest for PBFI. PBFI has been used for detecting adrenoceptor-stimulated decreases of intracellular K concentration in astrocytes and neurons, evaluating the mediating effects of K depletion on monocytic cell necrosis, measuring intracellular K fluxes associated with apoptotic cell shrinkage, monitoring mitochondrial KATP channel activation, or detecting elevated intracellular K levels associated with HIV-induced cytopathology.
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