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Medchemexpress LLC PCC0208017 | 2623158-64-3 | 99.5% | 403.40 | 100 MG
Supplier: Medchemexpress LLC HY139604100MG
PCC0208017 is an inhibitor of microtubule affinity regulating kinases MARK3 and MARK4, with IC50s of 1.8 nM and 2.01 nM, respectively. It suppresses glioma progression both in vitro and in vivo by disrupting microtubule dynamics, inducing G2/M phase cell cycle arrest, and promoting cell apoptosis. This compound has demonstrated robust antitumor activity and good blood-brain barrier (BBB) permeability.
- Inhibits MARK3 and MARK4 activity
- Suppresses glioma progression in vitro and in vivo
- Disrupts microtubule dynamics
- Induces G2/M phase cell cycle arrest
- Promotes cell apoptosis
- Demonstrates robust antitumor activity in vivo
- Possesses good blood-brain barrier permeability
- Decreases Tau phosphorylation
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