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Apexbio Technology LLC PCI-34051(Synonyms: PCI 34051, PCI34051, HDAC8 inhibitor PCI-34051, PCI-34051 HDAC inhibitor), 10mM (in 1mL DMSO), CAS: 950762-95-5.
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Supplier:  Apexbio Technology LLC A40915.1

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PCI-34051 (CAS 950762-95-5) is a selective inhibitor of histone deacetylase 8 (HDAC8) with over 200-fold specificity compared to other HDAC isoforms including HDAC1 HDAC2 HDAC3 HDAC6 and HDAC10 Through selective HDAC8 inhibition PCI-34051 preferentially triggers caspase-dependent apoptosis in T-cell lymphoma and leukemia-derived cell lines while sparing normal hematopoietic (e g PBMCs) and fibroblast cells Cell death induction by PCI-34051 occurs without detectable histone or tubulin hyperacetylation This compound serves as a valuable research tool for dissecting HDAC8-related pathways and evaluating therapeutic potential for hematologic malignancies

Catalog No. 50-000-60954


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