ABclonal Technology PCSK9 Rabbit mAb

Supplier:  ABclonal Technology A2521520UL

This gene encodes a member of the subtilisin-like proprotein convertase family which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network It is expressed in liver intestine and kidney tissues and escorts specific receptors for lysosomal degradation It plays a role in cholesterol and fatty acid metabolism Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia Alternative splicing results in multiple transcript variants

Catalog No. 50-000-10432