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ACROBiosystems Human PCSK9 (D374Y) Protein, His Tag, Low Endotoxin, 1 mg

Catalog No. 501658782
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Human PCSK9 (D374Y) is a recombinant protein expressed from human HEK293 cells. This protein, which contains a C-terminal polyhistidine tag, undergoes autocatalytic processing to form a mature complex of pro-peptide and active chain. The D374Y mutation is associated with increased affinity for the low-density lipoprotein receptor (LDLR), which regulates cholesterol homeostasis.

  • Greater than 90% purity as determined by SDS-PAGE and greater than 95% purity by SEC-MALS.
  • Less than 0.01 EU per μg endotoxin level measured by the LAL/rFC method.
  • Verified by LC-MS/MS peptide mapping with 98.0% sequence coverage.
  • Lyophilized formulation in PBS, pH 7.4 with trehalose as a protectant.
  • Recommended for long-term storage at -20°C or lower.

Catalog No. 50-165-8782 Supplier ACROBiosystems Supplier No. PCYH52251MG
May include imposed supplier surcharges.
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Human PCSK9 (D374Y) is a recombinant protein expressed from human HEK293 cells. This protein, which contains a C-terminal polyhistidine tag, undergoes autocatalytic processing to form a mature complex of pro-peptide and active chain. The D374Y mutation is associated with increased affinity for the low-density lipoprotein receptor (LDLR), which regulates cholesterol homeostasis.

  • Greater than 90% purity as determined by SDS-PAGE and greater than 95% purity by SEC-MALS.
  • Less than 0.01 EU per μg endotoxin level measured by the LAL/rFC method.
  • Verified by LC-MS/MS peptide mapping with 98.0% sequence coverage.
  • Lyophilized formulation in PBS, pH 7.4 with trehalose as a protectant.
  • Recommended for long-term storage at -20°C or lower.

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