AdipoGen PD-1 ms mAb blocking1H10

Supplier:  AdipoGen AG20B0075PFC500

Monoclonal Antibody. Recognizes mouse PD-1 CD279. Does not cross-react with human PD-1d. Isotype Rat IgG2akappa. Clone 1H10. Applications FACS, FUNC Blocking. Liquid. In PBS. CD279 Programmed Cell Death Protein 1 PD-1 is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation CD28 and ICOS or downregulate T cell activation CTLA-4 and PD-1. CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

Catalog No. 50-256-3374