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Medchemexpress LLC PD 144418 oxalate | 1794760-28-3 | 98.65% | 372.41 | 50 MG
Supplier: Medchemexpress LLC HY108512A10MG
PD 144418 oxalate is a highly affine, potent, and selective sigma 1 (σ1) receptor ligand. With Ki values of 0.08 nM for σ1 and 1377 nM for σ2, it does not show significant affinity for other receptors, ion channels, or enzymes. This compound exhibits potential antipsychotic activity.
- Highly affine, potent, and selective sigma 1 (σ1) receptor ligand
- Devoids significant affinity for other receptors, ion channels, and enzymes
- Shows potential antipsychotic activity
- Reverses NMDA-induced increase in cyclic GMP (cGMP) in rat cerebellar slices in vitro
- Potentiates the decrease in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region in vitro
- Antagonizes Mescaline-induced scratching in male CD-1 mice in vivo
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