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Medchemexpress LLC PD-168077 maleate | 190383-31-4 | 334.41 | 25 MG
Supplier: Medchemexpress LLC 25MGHY21098A
PD-168077 maleate is a selective dopamine D4 receptor agonist with a Ki of 9 nM. It is suitable for use in various research applications, including studies on neurological function and signaling pathways, and has shown significant effects in both cellular and in vivo models.
- Activates human dopamine receptor D4, stimulating mitogenesis in D4-transfected CHO pro-5 cells (EC50 of 17 nM).
- Exhibits agonist activity at human D4.4 receptor in HEK293 cells (EC50 of 8.3 nM).
- Induces dose-dependent locomotion and myoclonic jerking in animal models.
- Increases p-CaMKII clustering at synaptic sites, enhancing colocalization with PSD-95.
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