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Apexbio Technology LLC PD 173074 219580-11-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A82535.1
PD 173074 (CAS 219580-11-7) is a selective inhibitor targeting fibroblast growth factor receptors (FGFR) exerting its effects by suppressing FGFR tyrosine kinase phosphorylation It has demonstrated dose-dependent inhibitory activity against small cell lung cancer (SCLC) cell lines including H-510 and H-69 by reducing their proliferation colony formation and FGF-2 induced chemotherapy resistance in vitro In murine xenograft models of SCLC PD 173074 reduced tumor progression and significantly prolonged animal survival achieving durable complete responses in some cases PD 173074 represents an important tool compound for investigating the oncogenic role of FGFR signaling in cancer research
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