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Apexbio Technology LLC PD0325901 391210-10-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A30135.1
PD0325901 (CAS 391210-10-9) is a small-molecule inhibitor selectively targeting mitogen-activated protein kinase kinase (MEK) an integral kinase within the RAS/RAF/MEK/ERK signaling cascade This pathway commonly exhibits elevated activity in various human cancers and contributes to cell proliferation survival and differentiation Treatment with PD0325901 reduces phosphorylated ERK (P-ERK) levels in vitro indicative of MEK inhibition In mouse tumor models administration of PD0325901 has demonstrated suppression of tumor growth underscoring its value as a research tool for elucidating MEK-mediated signaling and evaluating therapeutic potential in oncology
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