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Apexbio Technology LLC PD173955 260415-63-2 5mg
SDP

Supplier:  Apexbio Technology LLC A88125

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PD173955 (CAS 260415-63-2) is a small-molecule inhibitor targeting Bcr-Abl Src and Yes tyrosine kinases with reported IC50 values of 1 2 nM 300 nM and 175 nM respectively Bcr-Abl is associated with oncogenic transformation while Src and Yes are implicated in tumor cell survival proliferation and invasion In cellular assays PD173955 inhibits KL-dependent proliferation of CML CD34 progenitor cells (IC50 50 nM) and reduces G2-M phase cell populations accompanied by an increase in G1 phase cells In HT29 and Bcr-Abl-dependent cell lines PD173955 suppresses proliferation and Src autophosphorylation This compound is widely used in studies investigating kinase signaling and cell cycle regulation in cancer research

Catalog No. 50-224-0226


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