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Apexbio Technology LLC PD173955 260415-63-2 5mg
SDP

Catalog No. 502240226
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PD173955 (CAS 260415-63-2) is a small-molecule inhibitor targeting Bcr-Abl Src and Yes tyrosine kinases with reported IC50 values of 1 2 nM 300 nM and 175 nM respectively Bcr-Abl is associated with oncogenic transformation while Src and Yes are implicated in tumor cell survival proliferation and invasion In cellular assays PD173955 inhibits KL-dependent proliferation of CML CD34 progenitor cells (IC50 50 nM) and reduces G2-M phase cell populations accompanied by an increase in G1 phase cells In HT29 and Bcr-Abl-dependent cell lines PD173955 suppresses proliferation and Src autophosphorylation This compound is widely used in studies investigating kinase signaling and cell cycle regulation in cancer research

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Catalog No. 50-224-0226 Supplier Apexbio Technology LLC Supplier No. A88125
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PD173955 (CAS 260415-63-2) is a small-molecule inhibitor targeting Bcr-Abl Src and Yes tyrosine kinases with reported IC50 values of 1 2 nM 300 nM and 175 nM respectively Bcr-Abl is associated with oncogenic transformation while Src and Yes are implicated in tumor cell survival proliferation and invasion In cellular assays PD173955 inhibits KL-dependent proliferation of CML CD34 progenitor cells (IC50 50 nM) and reduces G2-M phase cell populations accompanied by an increase in G1 phase cells In HT29 and Bcr-Abl-dependent cell lines PD173955 suppresses proliferation and Src autophosphorylation This compound is widely used in studies investigating kinase signaling and cell cycle regulation in cancer research

This item is not returnable. View return policy
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