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Enzo Life Sciences PD-98059, (5mg), CAS Number: 167869-21-8
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Supplier:  Enzo Life Sciences BMLEI3600005

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MEK inhibitor. PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest. Formula: C16N13NO3. MW: 267.3. CAS Number: 167869-21-8. Purity: ≥95% (HPLC). Appearance: Pale yellow solid. Solubility: Soluble in DMSO (6.5mg/ml); 25mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6mg/ml). Long Term Storage: -20°C

Catalog No. NC9621328


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