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STEMCELL Technologies PD98059, Size: 1 mg
Supplier: STEMCELL Technologies 72172
PD98059 is a selective, cell permeable inhibitor of the MEK/ERK pathway that acts by preventing the activation of MEK1 (IC₅₀ = 2 - 7 µM) and MEK2 (IC₅₀ = 50 µM) by upstream kinases. It does not inhibit activated MEK, or the p38 MAPK pathway. (Alessi et al., Davies et al., Dudley et al.)MAINTENANCE AND SELF-RENEWAL· Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Burdon et al., Qi et al.).· Permits derivation of mouse ES cells from the refractory CBA mouse strain (Buehr and Smith).DIFFERENTIATION· Blocks the differentiation of mouse ES cells (Burdon et al.).· Enhances adipogenic differentiation and blocks osteogenic differentiation of human mesenchymal stem cells (Jaiswal et al.).CANCER RESEARCH· Decreases number of AML blast colonies with minimal effect on normal hematopoietic progenitors (Milella et al.).
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