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Cayman Chemical PDE4B InhIbItr 1mg
Supplier: Cayman Chemical 327321 MG
A PDE4B inhibitor (IC50 = 140 nM); selective for PDE4B over a panel of 20 PDE isoforms and a panel of 39 CNS receptors at 10 µM; inhibits the activity of PDE4C1, PDE3B, 5-HT2C, and σ2 receptor by >50% activity at 10 µM; decreases LPS- or Pam3Cys-induced TNF-α production in mouse BMDMs at 1 µM; reduces cocaine self-administration and the progressive ratio breakpoint in mice at 5 mg/kg
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