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Genscript Corporation Antibody Protein Proteins Proteins 50 UG 1/EA

Supplier:  Genscript Corporation Z0317950

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Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA AB BB CC and DD) formed by 4 different PDGF subunits. In vivo PDGF-BB is mainly produced in heart and placenta and predominantly expressed by osteoblasts fibroblasts smooth muscle cells and glial cells. An inactive precursor of PDGF-BB is produced in the endoplasmic reticulum and then activated by a proprotein convertase after secretion. PDGF-BB functions in a paracrine manner and promotes organogenesis human skeletal development and wound healing. PDGF-BB also promotes angiogenesis particularly in the presence of Fibroblast Growth Factor basic. Therefore PDGF-BB and its related pathways are potential pharmacological targets.

Catalog No. 50-252-9736


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