PDL1 Detection Set, ProSci

Catalog No.	Quantity
16-595-572	1 Set

Catalog No. 16-595-572 Supplier ProSci LLC Supplier No. SD8500SET

Description

Llama Monoclonal Detection Sets

PDL1 Monoclonal specifically detects PDL1 in Human samples. It is validated for ELISA, Flow, ICC, IF

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

Specifications

• Antigen: PDL1
• Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Concentration: Antibody 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS containing 0.02% sodium azide.
• Host Species: Llama
• Immunogen: PD-L1 antibodies were raised against a recombinant protein corresponding to amino acids 19 - 239 of human PD-L1.
• Purification Method: PD-L1 Antibodies are affinity chromatography purified via Nickel column.Antibodies are supplied as a His-tagged purified protein. They also contains a myc-tag for detection.
• Quantity: 1 Set
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: PD-L1 antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Product Type: Detection Sets
• Form: Liquid