This gene encodes the receptor for urokinase plasminogen activator and given its role in localizing and promoting plasmin formation likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus However a soluble protein is also produced in some cell types Alternative splicing results in multiple transcript variants encoding different isoforms The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined