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ABclonal Technology PE Rabbit anti-Human CD146 mAb
Supplier: ABclonal Technology A23748200T
Melanoma cell adhesion molecule (MCAM MUC18 CD146) is an immunoglobulin superfamily member that acts as a cell surface adhesion protein and a marker of melanoma progression and metastasis It is expressed in vascular endothelial cells activated T lymphocytes smooth muscle and bone marrow stromal cells MCAM expression increases in endothelial cells in angiogenesis-related disorders including inflammatory bowel disease Crohn s disease rheumatoid arthritis tumors and chronic renal failure In the hematopoietic microenvironment MCAM-expressing human mesenchymal stromal cells (hMSC) maintain hematopoietic stem and progenitor cell (HSPC) self-renewal MCAM also plays a role in multiple sclerosis facilitating lymphocyte transmigration across the blood-brain barrier leading to inflammatory lesions in the central nervous system
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