Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Pemetrexed 150399-23-8 200mg
Supplier: Apexbio Technology LLC A4390200
Pemetrexed (CAS 150399-23-8) is a folate antagonist that targets multiple enzymes involved in the de novo synthesis of purine and pyrimidine nucleotides including thymidylate synthase (TS) dihydrofolate reductase (DHFR) glycinamide ribonucleotide formyltransferase (GARFT) and aminoimidazole carboxamide ribonucleotide formyltransferase (AICARFT) Structurally related to the antifolate compound lometrexol Pemetrexed disrupts nucleotide biosynthesis and subsequently inhibits DNA replication in proliferating cells It has demonstrated enzymatic inhibition across several pathways though exhibits limited cytotoxic activity in a range of tumor cell types such as non-small cell lung cancer mesothelioma breast colorectal cervical head and neck and bladder cancers This compound is widely used in preclinical studies of folate pathway inhibition and antimetabolite chemotherapy research
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?