PEPA, Tocris Bioscience™

Description

Allosteric potentiator of AMPA receptor desensitization

Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluA3/4 > GluA1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.

Specifications

• CAS: 141286-78-4
• Molecular Formula: C16H16F2N2O4S2
• Quantity: 50 mg
• Synonym: pepa, 2,6-difluoro-4-2-phenylsulfonylamino ethylthio phenoxyacetamide, 2-2,6-difluoro-4-2-phenylsulfonyl amino ethyl sulfanyl phenoxy acetamide, lopac-d-8941, pepa drug, 4-2-phenylsulfonylamino ethylthio-2,6-difluorophenoxyacetamide, 4-2-phenylsulfonylamino ethylthio-2,6-difluoropheno-xyacetamide, 2,6-difluoro-4-2-phenylsul-fonyl-amino-ethyl-thio-phenoxy-acet-amide, 2,6-difluoro-4-2-phenylsul-fonyl-amino-ethyl-thio-phenoxy-acetamide, 2-2,6-difluoro-4-2-phenylsulfonyl amino ethyl thio phenoxy acetamide
• InChI Key: GTACSIONMHMRPD-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
• IUPAC Name: 2-[4-[2-(benzenesulfonamido)ethylsulfanyl]-2,6-difluorophenoxy]acetamide
• Molecular Weight (g/mol): 402.431
• PubChem CID: 6603828
• Formula Weight: 402.44
• Percent Purity: >99%
• Chemical Name or Material: PEPA

Safety and Handling

Recommended Storage

Store at Room Temperature