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Apexbio Technology LLC Pertussis Toxin(Synonyms: PTX, Pertussigen, Pertussis toxin protein, Islet-activating protein, Pertussis toxoid), 50ug, CAS: 70323-44-3.
Supplier: Apexbio Technology LLC B72730.05
Pertussis toxin (CAS 70323-44-3) is an AB5-type protein exotoxin produced by Bordetella pertussis the bacterium responsible for whooping cough Mechanistically pertussis toxin modulates host immune responses primarily via a cAMP-dependent pathway as demonstrated by its actions on human monocyte-derived dendritic cells influencing their maturation and cytokine production In animal models treatment reduces norepinephrine-induced contractions in rat mesenteric resistance arteries without notable effects on mouse tracheal contractility Pertussis toxin serves as a research tool in immunological studies and is central to acellular pertussis vaccines designed to limit disease transmission and severity across susceptible populations
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