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Cayman Chemical Pexacerfont 10mg
Supplier: Cayman Chemical 3322110 MG
A CRF1 antagonist (IC50 = 6.1 nM); selective for CRF1 (mean IC50 = 10.6 nM) over CFR2β (IC50 = >1,000 nM) in radioligand binding assays and does not bind to the human CRF binding protein (IC50 = >1,000 nM); inhibits CFR-induced ACTH release in primary rat pituitary cells (IC50 = 129 nM); increases the time spent in the open arms of the EPM in rats at 10-30 mg/kg
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