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Medchemexpress LLC Pexidartinib (hydrochloride) | 2040295-03-0 | 99.8% | 454.28 | 20 G
Supplier: Medchemexpress LLC HY16749A20G
Pexidartinib hydrochloride is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor. It exhibits 10- to 100-fold selectivity for CSF1R and c-Kit over other related kinases and induces cell apoptosis with anti-cancer activity.
- Potent, orally active, selective, and ATP-competitive CSF1R and c-Kit inhibitor.
- Exhibits 10- to 100-fold selectivity for CSF1R and c-Kit over other related kinases.
- Induces cell apoptosis and has anti-cancer activity.
- Can be used to deplete microglia cells in mice.
- Reduces tissue macrophage levels without affecting glucose homeostasis in mice.
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