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Medchemexpress LLC PF-00446687 free base | 862281-92-3 | 98.0% | 470.59 g/mol | C28H36F2N2O2 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1062250MG

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PF-00446687 free base is a non-peptide, brain-penetrant small-molecule agonist of the melanocortin-4 receptor (MC4R) used in research on melanocortin signaling and central nervous system pharmacology. It is supplied as a powder for in vitro and in vivo studies and demonstrates low-nanomolar potency and selectivity.

  • Selective melanocortin-4 receptor agonist with EC50 12 ± 1 nM.
  • Binding affinity (Ki) approximately 27 ± 4 nM.
  • Brain-penetrant, suitable for central nervous system studies.
  • Provided as a powder with solubility in DMSO 62.5 mg/mL (ultrasonic recommended).
  • Molecular formula C28H36F2N2O2 and molecular weight 470.59 g/mol.
  • High purity by HPLC (≈98.0% per COA).
  • Storage: powder -20°C (long-term) or 4°C (short-term).

Catalog No. 50-002-41861


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