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Medchemexpress LLC PF-02413873 (PF-2413873) | 936345-35-6 | 99.9% | 359.44 | 50 MG
SDP

Catalog No. 5000343542
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PF-02413873 is a potent selective, fully competitive, and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. It can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo.

  • Potent selective, fully competitive, and orally active nonsteroidal progesterone receptor (PR) antagonist.
  • Ki of 2.6 nM.
  • Can block progesterone binding and PR nuclear translocation.
  • Can inhibit endometrial growth in vivo.
  • Shows potent PR antagonist activity with a derived Ki of 9.7 nM in the T47D native functional assay.
  • Induces nuclear translocation only at high concentrations (>3 μM) in vitro.
  • Induces a statistically significant reduction in endometrial thickness in cynomolgus macaques.
  • Exhibits t1/2 (4.2 h), Cmax (162 ng/mL), and CL/F (41 mL/min/kg) in cynomolgus macaques.

Catalog No. 50-003-43542 Supplier Medchemexpress LLC Supplier No. HY1102850MG
May include imposed supplier surcharges.
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PF-02413873 is a potent selective, fully competitive, and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. It can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo.

  • Potent selective, fully competitive, and orally active nonsteroidal progesterone receptor (PR) antagonist.
  • Ki of 2.6 nM.
  • Can block progesterone binding and PR nuclear translocation.
  • Can inhibit endometrial growth in vivo.
  • Shows potent PR antagonist activity with a derived Ki of 9.7 nM in the T47D native functional assay.
  • Induces nuclear translocation only at high concentrations (>3 μM) in vitro.
  • Induces a statistically significant reduction in endometrial thickness in cynomolgus macaques.
  • Exhibits t1/2 (4.2 h), Cmax (162 ng/mL), and CL/F (41 mL/min/kg) in cynomolgus macaques.

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